国际眼科纵览 ›› 2024, Vol. 48 ›› Issue (2): 87-92.doi: 10.3760/ cma.j.issn.1673-5803.2024.02.002

• 综述 • 上一篇    下一篇

TGF-β通路相关的后发性白内障发生机制

徐素 张宇航 司玮 张凤妍   

  1. 郑州大学第一附属医院眼科,郑州 450000
  • 收稿日期:2023-10-11 出版日期:2024-04-22 发布日期:2024-04-29
  • 通讯作者: 张凤妍,Email:zhangfengyanx@aliyun.com
  • 基金资助:
     国家自然科学基金(81970785)

The impact of regulatory factors on the TGF-β pathway on posterior capsule opacification 

Xu Su, Zhang Yuhang, Si Wei, Zhang Fengyan   

  1. Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000
  • Received:2023-10-11 Online:2024-04-22 Published:2024-04-29
  • Contact: Zhang Fengyan, Email:zhangfengyanx@aliyun.com
  • Supported by:
    National Natural Science Foundation of China (81970785)

摘要: 后发性白内障(posterior capsule opacification,PCO)是导致白内障患者术后视觉质量不佳的主要原因,在成年人术后发生率为30%~50%,在儿童中则高达100%。PCO的发病机制复杂,TGF-β通路影响了晶状体上皮细胞的上皮-间质转化及迁移,部分核糖核酸的表达、自噬或凋亡的发生均可通过调控TGF-β通路进而影响PCO形成,并可由此发掘可能预防PCO的潜在药物。 (国际眼科纵览,2024, 48:87-92)

关键词: 后发性白内障, 转化生长因子β, 晶状体

Abstract: Posterior capsule opacification (PCO) is the primary cause of compromised visual acuity in patients following cataract surgery, with an incidence ranging from 30% to 50% in adults and up to 100% in children. The pathogenic mechanism of  PCO is complex. The TGF-β pathway influences the epithelial-mesenchymal transition and migration of lens epithelial cells. The expression of certain ribonucleic acids, autophagy or apoptosis can exert influence on PCO formation, thereby leading to the identification of potential therapeutic agents for its prevention.  (Int Rev Ophthalmol, 2024, 48:  87-92)

Key words: posterior capsule opacification, transforming growth factor beta, lens